Internal Medicine

Instructions to Authors

Internal Medicine is a peer-reviewed, open-access online journal published every two weeks by the Japanese Society of Internal Medicine.

Articles must be prepared in accordance with "Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly Work in Medical Journals" (, must be contributed solely to the Internal Medicine, and become the property of the Japanese Society of Internal Medicine. Statements contained therein are the responsibility of the author(s). The Society reserves copyright and renewal on all published material and such material may not be reproduced in any form without the written permission of the Society.

All submitted manuscripts will be reviewed by the editors of Internal Medicine to evaluate the eligibility for publication. Eligible manuscripts will be sent to expert reviewers in the field of the study for peer review. Based on the evaluation by the reviewers and the editors, the editorial board decides whether the manuscript is either accepted for publication, returned for revision, or denied publication. If revision is requested, the authors should respond to each suggestion and comment by the reviewers and editors when submitting the revised manuscript.

Aims and Scopes

Internal Medicine (Intern Med) is peer-reviewed, open-access online academic journal published every two weeks by the Japanese Society of Internal Medicine, and aims to publish most complete and reliable source of information on the discoveries and current developments. Intern Med encourages submission of previously unpublished original manuscripts: experimental research article, clinical case and review articles.

The scope of the journal covers the areas including cohort study, case-control study, systematic review, meta-analysis, clinical medicine, clinical trials, experimental research, diagnosis and management of diseases, epidemiology and preventive medicine.

Intern Med is indispensable for clinical physician, internal medicine specialists and academicians and accepts articles from wide range within the field of Internal Medicine.


Papers reporting human subjects or animals should state that the procedures followed were in accordance with the Declaration of Helsinki. Such papers must include a statement that the human investigations were performed after approval by relevant institutional review board. Authors submitting manuscript containing data from experiments involving recombinant DNA molecules must provide a statement which certifies that their experiments complied with the appropriate guidelines approved by the governmental agencies on physical and biological containment procedures. Clinical studies using unapproved or off-label drugs must include a statement that the study was approved by the authors’ affiliated institutions and patients.

Internal Medicine will not accept articles, other than in the case of abstracts, in which a significant portion of the data in the form of figures and tables has been published or submitted for publication elsewhere. Copies of material that might be considered as prior or duplicate publication should be submitted with the manuscript and clearly marked as such so as not to be confused with the actual manuscript submitted. If duplicate submission or any unethical conduct is found, all authors listed in a manuscript will be held responsible and are subject to severe punitive measures by the Editorial Committee of Internal Medicine.

Internal Medicine will not accept manuscripts that report exclusively the results of animal experiments. However manuscripts reporting treatments using pharmaceutical products with animal-derived ingredients (vaccines, immune serums and other biological preparations), and reports of clinical trials with administration of animal-derived ingredients may be considered for review.

The use of artificial intelligence or similar technology (e.g., Chat GPT) in the writing of a paper does not count as authorship or co-authorship, and authors are responsible for its content and are required to indicate its use in the acknowledgments or text (except for use for grammar or spell checking).

Internal Medicine occasionally receives letters referring to a recent article in Internal Medicine. The author(s) should respond rapidly when the Editorial Board requests the author to submit his/her reply to the letters.

Manuscript Submission

Authors should submit their manuscripts to the Internal Medicine manuscript online :
Main document must be typed double-spaced with wide margins. Tables and Figures should be uploaded separately from the main document. Arrange the paper in the following order:(1)title page;(2)abstract;(3)text,(4)references;(5)figure legends.

Incomplete or improperly prepared manuscripts will be returned to authors without review.

Submission Fee

Starting 0:00 AM, September 1, 2015 (Japan Time), a submission fee of $300 (USD) is applicable to all manuscripts submitted by the NON-MEMBERS of the Japanese Society of Internal Medicine (JSIM). This is also required when resubmitting a manuscript that was previously rejected. The fee is applicable to all types of manuscripts.

Submission fee is waived only if the first author of the manuscript is a member of the Japanese Society of Internal Medicine.

The submission fee must be paid via PayPal (no alternatives). Once you complete submitting your manuscript from Internal Medicine's manuscript submission site
(, you will receive a submission confirmation e-mail, which contains the instruction for making a payment.

The submission fee is NON-REFUNDABLE.

Self-reported Potential COI (Conflict of Interest) Disclosure Statement *Please provide your COI in the "Personal Financial Interests" section of the manuscript submission system.

When submitting a manuscript to Internal Medicine, all authors are required to disclose any financial relationship within the past 36 months (3 years) with any biotechnology manufacturer, pharmaceutical company, or other commercial entity that has an interest in the subject matter or materials discussed in the manuscript.

The matters requiring disclosure are outlined as follows:

Copyright Transfer

The authors required to agree that the copyright for this article is transferred to the Japanese Society of Internal Medicine (JSIM) if and when the article is accepted for publication.

JSIM holds copyright to all articles and their contents published in the Internal Medicine. However, anyone may access, download, copy, and redistribute articles published in the Internal Medicine for non-profit purposes and personal use with the indication of original authors and sources: an author's name, Journal's name, Volume and number , illustrating the quoted sentences (except in the case of distributing the modified material). All articles and their contents published in the Internal Medicine may not be used for profit or commercial use, without the prior written permission by JSIM.

The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (


To protect the privacy of the patients, any personal data such as the followings cannot be included in the manuscript; patient's name or initials, patient ID number, address (only prefecture or state is acceptable), specific dates by which clinical course can be identified (dates should be expressed as the early, middle or end of a specific month), photographs of patient's face (photographs which focus on the affected area without identifying a patient can be used). Written consent must be obtained from individual participants (or guardians of participants) prior to the study and must be presented when requested by the Editorial Office.

Category of Manuscript

Original Article

The editors of the Internal Medicine welcome concise original articles devoted to internal medicine and its subspecialities.

Abstracts for Original Articles are limited to 250 words and should be structured according to the following Format:
Objective, Methods, Patients or Materials, Results, Conclusion.

A list of two to six key words and subjects that will be useful for indexing or searching should be added to the bottom of the abstract page.

The word count for this category of manuscript should be 3,500 or less (excluding references, tables, and figure legends) with no limitations on the number of figures or tables.

Case Report

Reports of clinical cases are welcome.

Abstracts for Case Report are limited to 100 words.

A list of two to six key words and subjects that will be useful for indexing or searching should be added to the bottom of the abstract page.

Editors may recommend the authors to submit the manuscript as Pictures in Clinical Medicine. In such case, the authors are encouraged to re-submit under the category of Pictures in Clinical Medicine.

There is no word limit, figure/table limit for this category of manuscript.

Review Article

Review articles are usually solicited by the editors, but we will consider unsolicited material. Abstracts for Review Article are limited to 150 words.

A list of two to six key words and subjects that will be useful for indexing or searching should be added to the bottom of the abstract page.

The word count should be 4,000 words or less (excluding references, table, figure legends) and figure/table no limit for this category of manuscript.

Letters to the Editor

Letters referring to a recent article in Internal Medicine are considered for publication (subject to editing and abridgment).

Letters do not exceed 400 words of manuscript text with no more than 5 references.

Letters should not duplicate similar material being submitted or published elsewhere, and they should not contain abbreviations.

Letters referring to a recent article in Internal Medicine must be received within two months of the article's publication.

A list of two to six key words and subjects that will be useful for indexing or searching should be added to the bottom of the abstract page.

Pictures in Clinical Medicine

Images depicting an instructive case, a novel finding and/or element of current interest for clinical medicine.

The manuscript text should not exceed 150 words with up to 2 references.

The picture legend should not be contained.

The title should be concise and contain up to 8 words and there should be no more than 4 pictures.

Only 4 authors may be listed.

Units of Measurement

All measurements must be expressed in metric system and/or the Systeme International d'Unites (SI).

Use a capital letter "L" for liter in the units of measurements in the Text, Figures and Tables (g/dL, mg/dL, IU/L, mg/dL, mEq/L) .

Title Page

Include first name, degree, and affiliation for all authors.

Indicate the institution of each author (city and country) at time of study.

Include (as a footnote) the name and address of institution from which work originated plus information about grants, and the name and E-mail address of the person to whom reprint requests should be sent.

Key Words

A list of two to six key words and subjects that will be useful for indexing or searching should be added to the bottom of the abstract page.


Using parentheses, cite each reference, figure and table in numerical order [ex.(4, 8-10);(Fig. 2);(Table 3)]. Order of mention in text determines the number given to each.

Place acknowledgements at end of text, before references.


Number in order of mention.

Provide inclusive page numbers for all journal references and book chapters, and the specific page numbers for book references. Indicate all abstracts as "(Abstract)."Use abbreviations for the names of all journals listed in Index Medicus. For those not listed, spell out the full name of English language journals. When the main text is not in English,use the original language name of the journal and include "(in language)" after the date.

If the official English translation of the name of the journal is printed on the cover,include the English name in parentheses after the original name. If only the abstract is in English,include "(Abstract in English)".

Citations to unpublished work should not be entered in the list of references unless the paper has been accepted for publication. Include them in the text as "(unpublished observation)","(personal communications)", or "(manuscript in preparation)", with authors' initials and surnames.

Personal communication must be accompanied by a copy of the correspondence or a letter from the correspondent to this editorial office.

Follow general arrangement, abbreviations and punctuation as given in Uniform Requirements for Manuscripts Submitted to Biomedical Journals. For periodicals, follow INDEX MEDICUS, listing all authors when six or fewer, when seven or more,list only first three and add "et al."

Please note that no periods are used after authors' initials. Sample references are as follows:

  1. Gottlieb SS,McCarter RJ. Vogel RA. Effect of beta-blockade on mortality among high-risk and low-risk patients after myocardial infarction. N Engl J Med 399:489-497, 1998.
  2. Sugiyama Y, Takei H, Tsuyuzaki H, et al. A Case of IgG4-related Disease Presented as Pericardial Effusion. Nihon Naika Gakkai Zasshi (Journal of Japanese Society of Internal Medicine) 103:1180-1182, 2014 (in Japanese).
  3. Swash M, Schwartz MS. Neuromuscular Disease. A Practical Approach to Diagnosis and Management. 3rd ed. Springer-Verlag, London, 1997:89-120.
  4. Wetzler M, Bloomfield CD. Acute and Chronic Myeloid Leukemias. in : Harrison's Principles of Internal Medicine. 14th ed. Fauci AS, Braunwald E, Isselbacher KJ, et al Eds. McGraw-Hill, New York, 1998:684-695

Figure Legends

Start at top of new page.

Number pages in sequence after last page of references.

Identify at the end of each legend and in alphabetical order all abbreviations in the figure described.

When arrows are used in the figure, indicate the specific feature in the figure legend followed by "(arrow)".

Indicate magnification for all photomicrographs.


Give each table a number (in Arabic numerals: Table 1, 2, etc.) and a title. Number the tables in the order in which they are mentioned in the text.

Do not use vertical rules within body of tables.

Provide a footnote to each table, identifying all abbreviations used.

Limit tables to number and size necessary for clarity.


Use black ink for all charts (line drawings). Make decimals, broken lines, etc., strong enough for reproduction when reduced to column width, two-column width, or intermediate width.

Do not combine very large type with very small type; all lettering should be of approximately equal size.

Use arrows to designate special features.

Crop photomicrographs to show only essential field.

Do not title the figure; this information should be included in the figure legend.

Carefully consider proportion for each part of a multipart figure.

Number figures in order in which they are mentioned in the text.

Submit written permission from publisher and author to reproduce any previously published figures.

Limit figures to number necessary for clarity.

When including a photograph, which a patient is identifiable, the patient's informed consent and the agreement to publish must be submitted.

(Updated, June 11, 2018)

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